An Introduction to Biomechanics: Solids and Fluids, Analysis by Jay D. Humphrey, Sherry L. O'Rourke

By Jay D. Humphrey, Sherry L. O'Rourke

This e-book covers the basics of biomechanics. subject matters comprise bio solids, biofluids, pressure, stability and equilibrium. scholars are inspired to contextualize rules and routines inside a “big photograph” of biomechanics. this can be an amazing publication for undergraduate scholars with pursuits in biomedical engineering.

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In reality, however, we know that water is a collection of discrete, interacting molecules composed of hydrogen and oxygen atoms, and we know that there are gaps between the H2O molecules and even gaps between the electrons and nucleus of each of the atoms. In statistical mechanics, we attempt to describe the (statistical) mean behavior of the individual molecules so as to understand gross behaviors on a natural scale of observation. In continuum mechanics, we also consider a volume-averaged mean behavior, but one that is independent of any consideration of the individual molecules.

This question becomes more acute when we realize, for example, that vascular smooth muscle cells independently express different genes in response to the changing 24 1. Introduction hemodynamics even though they are not in direct contact with the pressuredriven blood flow. As noted by Zhu et al. (2000), which is a very readable, nice review of cell mechanics, critical questions are as follows: How do forces applied to a tissue distribute around the surface of a cell? How are these forces balanced within the interior of the cell?

It consists of a polypeptide chain of $786 amino acid residues, the majority of which are glycine, alanine, and proline. Elastin is synthesized in minutes, as the precursor tro proelastin, via normal pathways—mRNA, endoplasmic reticulum, Golgi apparatus, and so forth. Moreover, it appears that synthesis can be assumed to be a first-order process, one that is completed in less than 1 h (Davidson and Giro 1986). In the vasculature, this synthesis is accomplished primarily by smooth muscle, but also by specialized fibroblasts and, perhaps, endothelial cells.

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